Soulver!
I bought the iPhone version - best calculating experience
since the old HP RPN times. Enter your queries in the left pane,
immediately see your results on the right.
UI designers - take a deep breath and a good look! Just in case you care: Mac OS only.
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Update (March 25th): The guys from SpeedCrunch notified me of their
(free and open source) alternative, running on a plethora of platforms (aah, it's Qt).
Thanx, I'm impressed. It makes me double my effort to find myself some free time to fiddle around with Qt...